Title of article
Synthesis and hypolipidemic activity of N-phthalimidomethyl tetra-O-acyl-α-d-mannopyranosides
Author/Authors
Rajendra M Srivastava، نويسنده , , Fernando J.S Oliveira، نويسنده , , Ladjane P da Silva، نويسنده , , Jo?o R de Freitas Filho، نويسنده , , Shalom P. Oliveira، نويسنده , , Vera L.M Lima، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
6
From page
335
To page
340
Abstract
A facile synthesis of anomerically pure phthalimidomethyl 2,3,4,6-tetra-O-acetyl- and phthalimidomethyl 2,3-di-O-acetyl-4,6-di-O-benzoyl-α-d-mannopyranosides (6 and 9b) starting from N-hydroxymethylphthalimide and tri-O-acetyl-d-glucal is described. Compounds 3, 6, 8, 9a and 9b have been tested for their hypolipidemic activity in mice. All these compound showed significant reduction of plasma cholesterol and triglyceride levels. Compound 9b has been found to possess the highest activity.
Keywords
?-d-Mannopyranoside , Tri-O-acetyl-d-glucal , N-Hydroxymethylphthalimide
Journal title
Carbohydrate Research
Serial Year
2001
Journal title
Carbohydrate Research
Record number
963215
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