Title of article
Concise chemoenzymatic synthesis of epi-inositol Original Research Article
Author/Authors
Cecilia Vitelio، نويسنده , , Ana Bellomo، نويسنده , , Margarita Brovetto، نويسنده , , Gustavo Seoane، نويسنده , , David Gonzalez، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2004
Pages
6
From page
1773
To page
1778
Abstract
epi-Inositol was synthesized in six steps in 40% overall yield from a bacterial bromobenzene metabolite. The chemoenzymatic route involved toluene dioxygenase oxidation, substrate-directed catalytic osmylation, m-CPBA epoxidation, radical debromination, and Amberlite-catalized hydrolysis. The route described is amenable to scaleup and could allow access to cis-inositol, and deoxy derivatives of epi-inositol.
Keywords
Haloepoxide , Dioxygenase , Chemoenzymatic , epi-Inositol , cis-Inositol
Journal title
Carbohydrate Research
Serial Year
2004
Journal title
Carbohydrate Research
Record number
964149
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