Title of article
Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives Original Research Article
Author/Authors
David Soriano del Amo، نويسنده , , Wei Wang، نويسنده , , Christen Besanceney، نويسنده , , Tianqing Zheng، نويسنده , , Yizheng Fan، نويسنده , , Brian Gerwe، نويسنده , , Ronald D. Seidel III، نويسنده , , Peng Wu، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2010
Pages
7
From page
1107
To page
1113
Abstract
A combination of recombinant FKP and α-(1→3)-fucosyltransferase allows the facile synthesis of the sialyl Lewis X tetrasaccharide glycan and its derivatives in excellent yield. In this system, the universal fucosyl donor, guanidine 5′-diphosphate-β-l-fucose (GDP-fucose), or its analogues can be generated in situ by cofactor recycling using pyruvate kinase.
Keywords
Chemoenzymatic synthesis , Transferases , Sialic acid , Fucose
Journal title
Carbohydrate Research
Serial Year
2010
Journal title
Carbohydrate Research
Record number
966988
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