Title of article
Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania Original Research Article
Author/Authors
Rémy Dureau، نويسنده , , Florence Robert-Gangneux، نويسنده , , Jean-Pierre Gangneux، نويسنده , , Caroline Nugier-Chauvin، نويسنده , , Laurent Legentil، نويسنده , , Richard Daniellou، نويسنده , , Vincent Ferrières، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2010
Pages
7
From page
1299
To page
1305
Abstract
The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.
Keywords
UDP-furanoses , Leishmania , Hexofuranosides , Visceral leishmaniasis
Journal title
Carbohydrate Research
Serial Year
2010
Journal title
Carbohydrate Research
Record number
967012
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