Title of article
A practical synthesis of capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates Original Research Article
Author/Authors
Henrik Gold، نويسنده , , Stefan Munneke، نويسنده , , Jasper Dinkelaar، نويسنده , , Herman S. Overkleeft، نويسنده , , Johannes M.F.G. Aerts، نويسنده , , Jeroen D.C. Codée، نويسنده , , Gijs A. van der Marel، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2011
Pages
12
From page
1467
To page
1478
Abstract
The synthesis of hyaluronan dimers and tetramers equipped with a 4-methylumbelliferyl group at the reducing end to potentially allow monitoring of hyaluronidase activities is described. The 4-OH at the non-reducing glucuronate in the presented series is either removed or methylated to prohibit transglycosylase reactions, leading to a total of four probes.
Keywords
Hyaluronan , Fluorogenic substrate , Hyaluronidase , Barton deoxygenation , Glycosylation
Journal title
Carbohydrate Research
Serial Year
2011
Journal title
Carbohydrate Research
Record number
967207
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