مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

H ydrogels produced by in situ polymerization have been extensively studied as biomaterials in applications such as scaffolds for tissue engineering and drug delivery systems. In situ polymerization process allows the hydrogel to be generated in vitro or in vivo from a low viscosity solution of monomer or low molecular weight polymer by free radical pathway. In this study, polyethylene glycol-diacrylate (PEG-DA) macromer has been synthesized by esterification of PEG with acryloyl chloride and characterized by NMR and FTIR spectroscopies and swelling study. Cross-linking was initiated by a pair of redox initiator, i.e. ammonium persulphate and A/,A/,A/י,A/-tetramethylethylenediamine. The conversion rate of the macromers to a cross-linked network was determined using 1H NMR and dynamic oscillatory test at 37°C and continuous disappearance of vinyl group upon addition of redox agent to a macromer solution was evaluated.