مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

Patients with IGT have increased risk of developing DM type II and non-communicable diseases in the future. The aim of this study was to determine the features of patients with IGT in Tehran and the correlation of IGT with other variables and risk factors of non communicable diseases. Materials and Methods: This study was a descriptive analytical and cross-sectional one, in which 960 of 9204 persons, participants of the first phase of Tehran Lipid and Glucose Study (TLGS) were found to have IGT in the initial assessment; eight weeks later, a second OGTT was done, and 331 had IGT. DM and IGT diagnosis were based on WHO criteria; in this group, anthropometric indices, BP, serum glucose, and lipid level were assessed after 12 hours of fasting. Obesity was defined as BMI> = 30 kg/m2 and over weight as BMI between 25 and 29.9 kwm2. WHR over 0.8 in females and 0.95 in males were defined as truncal obesity. Hypertension was defined as SBP> =140 or DBP> =90 mmHg or taking anti hypertensive drugs. Statistical analyses were performed using independent T-test, and ANOVA Results: Totally 331 patients with IGT were studied, of whom 232 (70%) were female and 99 (30%) were male. In 43% of cases, BMI was > = 30. WHR was abnormal in 83.7%; total cholesterol level in 32% was > = 240 mg/dl., LDL in 28.1% was > = 130 mg/dL and ? = 160 g/dL in 24.8%; HDL in 32.9% of cases was <35 mg/dl., In 43.2% of cases, TG was > = 200 mg/dl., Assessment of parameters according to BMI showed that mean cholesterol and triglyceride levels in obese patients were higher than the rest (p<0.05, p<0.001) and mean HDL cholesterol in obese patients was lower (p<0.ill4). Exercise tolerance test (EIT) was performed in 199 patients, and was positive in 14%. Conclusion: According to the results of this study, patients with IGT have a high risk of cardiovascular events because of multiple risk factors such as obesity, hypertension, smoking, and hyper lipidemia.