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Simultaneous Maxillary and Mandibular Brown Tumors in Secondary Hyperparathyroidism: A Case Report

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Hyperparathyroidism (HPT) is a disease, which results from increased secretion of parathyroid hormone (PTH). Primary HPT results from autonomous hyperplasia or a tumor in parathyroid and secondary HPT is usually associated with decreased calcium level due to chronic renal disease. Brown tumors have been seen occasionally at the terminal stages of HPT. A case of 19-year-old man with history of end-stage renal disease (ESRD) demonstrating two expansive lesions in jaws is reported here. PTH and alkaline phosphatase (ALP) were extremely high and consequently, a diagnosis of secondary HPT was established. Contrary to the typical secondary HPT, the patient was normocal-cemic. Computed tomography scan showed mixed radiolucent-radioopaque pattern of lesions and ossifications were significant. Surgical excision was carried out and histology revealed presence of fibro-endothelial connective tissue with broad areas of osteoids and numerous multinucleated giant cells, as seen in cases of brown tumors.

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