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Effect of Nepeta glomerulosa Boiss. Aerial Parts Aqueous Extract on Morphine Withdrawal Syndrome in Mice

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The effect of aqueous extract of Nepata glomerulosa Boiss. aerial parts on morphine withdrawal syndrome was investigated in mice. Dependence was induced by subcutaneous injections of morphine for 3 consecutive days. On day 4, morphine was injected 2 h prior to intraperitoneal injection of naloxone. The number of jumps during a 20 min. period after naloxone injection was considered as a measure of the withdrawal syndrome. Open field and rotarod tests were also performed. The results indicated that the aqueous extract (0.1 to 2.8 g/kg, s.c.) and diazepam (5 mg/kg) reduced the number of jumps (58±2.3 to 10±0.82, p<0.001 vs normal saline, 87±3.4). The extracts also reduced motion balance and locomotion activity. It is concluded that the aqueous extract of N. glomerulosa aerial parts could diminish morphine withdrawal syndrome.

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