شماره ركورد
19713
عنوان به زبان ديگر
Synthesis and in vitro Cytotoxicity Studies of Novel Triazolo[4,3-b]pyridazinones
پديد آورندگان
Rakib E.M. نويسنده , Abouricha S. نويسنده , Hannioui A. نويسنده , Benchat N. نويسنده , Zyad A. نويسنده , Ait M’barek L. نويسنده
از صفحه
272
تا صفحه
276
تعداد صفحه
5
چكيده لاتين
New triazolo[4,3-b]pyridazinones were synthesized and evaluated for their potential in vitro cytotoxic antitumor properties.
The compounds were prepared by 1,3-dipolar cycloaddition of pyridazin-3-ones with N-aryl-C-ethoxycarbonylnitrile imines,
generated in situ from ethylhydrazono-ل-bromoglyoxylates. The peri- and regioselectivity of the reaction were ascertained by 1H
and 13C NMR spectroscopy of the cycloadducts.
شماره مدرك
1203722
لينک به اين مدرک