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Evaluation of Changes in Serum Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein 3 in Children with Adenotonsillar Hypertrophy Before and After Surgery.

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Circulating concentrations of Insulin-Like Growth Factor-1 (IGF-1) and Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) are strongly related to diurnal GH secretion, reflecting mean daily serum GH levels. This interventional experiment studied serum levels of IGF-1 and IGFBP3 of 30 boys of 3-8-years old with grade 3 and 4 adenotonsillar hypertrophy before and after adenotonsillectomy (T and A surgery). Fasting levels of serum growth hormone biochemical markers (IGF-1 and IGFBP3) were measured on the morning of T and A surgery and 4-5 months postoperatively. IGF-1 and IGFBP3 serum levels were significantly increased in these patients after T and A surgery (p<0.01). Therefore Grade 3 and 4 adenotonsillar hypertrophy could be considered as major factors for prompts reduction of both IGF-1 and GIFBP3.

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