عنوان به زبان ديگر :
Determining the Inter- and Intraobserver Reproducibility of the Diagnosis of Endometrial Hyperplasia Subgroups and Well-Differentiated Endometrioid Carcinoma in Endometrial Curettage Specimens
پديد آورندگان :
Izadi-Mood Narges نويسنده , Khaniki Mahmood نويسنده , Irvanloo Guity نويسنده , Ahmadi Ali نويسنده , Hayeri Hayedeh نويسنده , Meysamie Alipasha نويسنده
چكيده لاتين :
Background: Many studies have attempted to identify histologic features that help to distinguish atypical hyperplasia from hyperplasia without atypia and well-differentiated endometrioid carcinoma of the endometrium; however, few have evaluated the reproducibility of these diagnoses.
Methods: Five pathologists independently reviewed 100 endometrial curettage specimens chosen to represent the spectrum of proliferative lesions of the endometrium. This included simple hyperplasia, complex hyperplasia, atypical hyperplasia, and well-differentiated endometrioid carcinoma. Slides were reviewed once for interobserver agreement among the five pathologists and twice for intraobserver agreement by one of them.
Results: The results were assessed using the weighted kappa statistic. The mean intraobserver kappa value was 0.86. The mean interobserver kappa values by diagnostic category were as follows: simple hyperplasia without atypia: 0.74; complex hyperplasia without atypia: 0.33; atypical hyperplasia: 0.34, and well-differentiated endometrioid carcinoma: 0.64; with a kappa value of 0.53 for all cases combined.
Conclusion: A major interobserver discrepancy exists in the diagnosis of complex and atypical hyperplasia which are the most similar mimics of endometrioid carcinoma.
