Histopathological study in Lungs of mice implanted with mammary adenocarcinoma (AM3) and treated with flavonoids (apigenin)

Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, had a role as anti-oxidant activity and regulate the redox status and prevent damage caused by oxidative stress. The present study aimed to investigate the hitopahtological changes may occurred in pulmonary tissues of mice implanted with mammary adenocarcinoma AM3 and treated with flavonoid. A sixty mice bearing-mice tumor and normal mice divided into G1; (n=3) bearing-AM3 tumor and treated with flavonoids (apigenin) 300mg/kg b.w/orally and daily/30 days, G2; (n=3) mice bearingtumor only, G3; (n=5) mice treated with flavonoids (apigenin) 300mg/kg b.w/orally /30days, G4; (n=5) as control group treated with D.W. The results of hematoxylene and eosin stained tissues of lung revealed significant histologic changes in tumorbearing mice of chronic bronchiolitis, interstitial pneumonia and alveolar emphysema, while in treated bearing-mice with flavonoid showed perivascular cuffing, no metastasis seen.Conclusion; apigenin has a significant anti-neoplastic role against implanted tumorto prevent infiltration and invasion of tumor cells to distant region.