ASSAY OF DICLOFENAC SODIUM TABLETS FROM DIFFERENT PHARMACEUTICAL MANUFACTURING SOURCES IN IRAQI PHARMACEUTICAL MARKETS

تحديد كمية المادة الفعالة لحبوب ديكلوفيناك الصوديوم المصنعة من شركات دوائية عدة والمتوفرة في الاسواق الصيدلانية العراقية

Diclofenac sodium is a non-steroidal anti-inflammatory analgesic drug used in the relief of pain and inflammation witch associated with certain conditions. It can be assayed using HPLC to estimate the weight of the active constituent of the drug in various dosage forms. In this work we studied four commercial brands of the oral dosage form of the drug from different pharmaceutical companies in the Iraqi pharmaceutical market, to evaluate the content of the drug in these brands.This has been achieved by making a calibration curve, using standard solutions of different concentration of the external standard diclofenac sodium u.s.p. different readings of the area under the peak were obtained following the straight line equation. Diclofenac was extracted from the tablet and injected in to HPLC system to measure the area under the peak from which we calculate the concentration then we evaluate the weight of the active constituent of the drug.