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Background: Diabetes is one of the major health concerns . Omega 3 and Omega 6 balanced ratio is important to maintain good health . Omega 3 and Omega 6 correct imbalances in modern diet that lead to health problems . The higher the ratio of Omega 6| Omega 3 the higher the health rate from many diseases. The optimum ratio must be less than 4: 1 that was related to less mortality(70% less). Flaxseed is noted one of the richest non animal source of Omega 3 fatty acids . Objective: This study aimed to: Investigate the effect of adjusting dietary Omega 6 : Omega 3 ( 2.17: 1) fatty acids ratio in diabetic rats on blood glucose, lipids and histopathological parameters with focus on pancreas and kidney . This ratio is occurred in the experiment diets by adding either flaxseed or flaxseed oil . Design: 27 diabetic rats were divided into 3 groups (9 rats each), first group was diabetic positive control, the second was flaxseed and the third was flaxseed oil . Nine normal rats were fed basal diet and served as negative control group. Blood samples were collected weekly for glucose monitoring while blood lipids were measured each two weeks. All animals were sacrificed after 6 weeks, organs were weighed and specimens from the kidney and pancreas were taken. Results: Results showed that treatment with balance ratio of Omega 6 : Omega 3 by flaxseed and flaxseed oil brought sugar level back to near normal level as negative control and had also an effective role in controlling , the increase in total cholesterol in diabetic rats compared with (PC) group . It also has great histopathological effect through stopping and limiting damage in langerhans islet moreover can restore pancreas cells as mitosis division was shown in histopathology . Marked regression was also found in kidney cells of both treated group.

adjusting Omega6 , ratio through flaxseed , blood and histological parameters , diabetic rats

2019

بحوث في العلوم و الفنون النوعيه

بحوث في العلوم و الفنون النوعيه