Enhancement effect of almond oil on transdermal penetration of flurbiprofen topical gel

Flurbiprofen is related to nonsteroidal anti-inflammatory drugs. The aim of this study is toinvestigate use of almond oil as enhancer to increase drug skin penetration. Five selectedformulas of flurbiprofen gel with five different concentration of almond oil were prepared. Onlyone formula was prepared without almond oil. The prepared gels were evaluated for severalphysico-chemical parameters to justify their suitability for topical use. The in vitro drug release studies were carried out by using Franz cell diffusion apparatus across synthetic membrane. The permeation profil e of various formulations also showed that the adding an enhancer in individualformula affected the permeation of the drug. Drug permeation increased with increasedconcentration of almond oil.