Spectrophotometric Determination Of Chlorpromazine Hydrochloride By Oxidative Coupling Reaction With Picric Acid Using Sodium Periodate

A simple and accurate spectrophotomitric method for determination of chlorpromazine )CPZ( in pure form and in dosage forms. The current method was developed based on chlorpromazine oxidative coupling reaction using picric acid in presence of sodium periodate to form red product was measured at 526 nm. Beer s law was in the linear range 4 - 60 μg/ml of CPZ, the molar absorptivity, Sandellʼs sensitivity index and detection limit were (0.5×10^4 ) liter. mol^-1.cm^-1, 0.0592 μg.cm^-2 and (0.355)μg/ml respectively. The RSD value was (0.154 ) % depending on the concentration. The results showed that this method can be successfully applied for the determination of CPZ in pure and in pharmaceutical formulations.