تقييم فعالية العلاج بالايزوتريتنوين عند مرضي العد الشائع في مشفي الاسد الجامعي باللاذقية

This study included 81 patients ( 24 male and 57 female ), whose ages varied from 15 to 30 years ( mean age 22.5 years) with moderate to severe acne, who were treated with isotretinoin in doses ranging from 0.5 to 0.75 mg/kg / day for a period ranging from 4-6 months, total cumulative dose 75 to 112.5 mg / kg ( mean 93.75 mg /kg). The patients were followed–up monthly for clinical development, side effects and laboratory advers effects .84% of patients achieved excellent response, 13.6% good and 2.4%weak. The main side effects are dryness of lips and nasal mucosa, arthralgia / myalgia and mild to moderate elevation in lipids and liver enzyme levels. According to our results, isotretinoin is effective and its side effects can be tolerated if we give the dose suitable to clinical evidence to the patient who has normal laboratory results.