التحضير الدوائي عند الأطفال الخاضعين للتنظير الهضمي

Intravenous midazolam and opioids are used to produce conscious sedation in children undergoing esophagogastroduodenoscopy (EGD). However, children may experience significant fear and anxiety before receiving these medications, especially during separation from parents and during venipuncture. Intranasal administration of midazolam represents a noninvasive method of sedating children before anxiety-producing events. The objective of this study is to determine whether premedication with intranasal midazolam reduces stress and anxiety of separation from parents and of undergoing venipuncture, while maintaining adequate sedation during EGD. Premedication with intranasal midazolam is effective in reducing negative behavior during separation from parents, while maintaining sedation during the endoscopic procedure. However, the benefits of intranasal administration may be affected by irritation and discomfort caused by intranasal drug administration.