دراسة تاثير العامل المفكك والمزلق وطريقة التحضير على تحرر السيناريزين من مضغوطات القالب مطولة التاثير

Higuchi The aim of this study was to evaluate the effect of some formulation variables and preparing method on the properties, especially drug release, of prolonged-release matrix tablets of cinnarizine prepared with ethyl cellulose as a release sustaining polymer. Wet granulation was used for the preparation. Powders, granules and tablets were tested for each formulation. One formulation was prepared by direct compression to evaluate the effect of preparation method on drug release. The results of study revealed that the total amount of cinnarizine released throughout 24 hours increased when starch was replaced by sodium alginate, and when talc and magnesium stearate were replaced by sodium benzoate or when tablets were prepared by direct compression instead of wet granulation. Cinnarizine was released by anomalous diffusion in acidic medium while it was released according to Higuchi model in phosphate buffer medium (pH=6.8)