تاثير التدخين المزمن للسجائر على حجم الزفير الاقصى في الثانية الاولى (FEV1) والجريان الزفيري الاعظمي الاوسطي بين 25-75% من السعة الحيوية (FEF25-75 ) و دورهما في التحري الباكر عن الداء الرئوي الساد

This study is conducted to assess the the effect of chronic cigarette smoking on FEV1,FEF25-75 and their role in early detecting of COPD. Subjects aged 40 years or older and who smoke 10 packs per year or more (n=110) were selected . The smoking histories of these subjects were investigated using a self-reported questionnaire. There were 5 smokers with restrictive disease , these patients were removed because they should be referred for further lung function. Percent predicted values of measured spirometric parameters of( FEV1, FEF25-75 ) decreased significantly with increasing pack-years (p-value <0.05 for male and female ) and there was an increasing in chronic respiratory symptoms frequency , so these Indices decrease must be considered as high risk to develop COPD . According to the interpretation of spirometric results, %63 smokers had normal spirometry while 37% smokers had confirmed COPD. Using (GOLD) severity criteria, smokers having COPD (87% male and 13% female ),these patient were divided into grades I ( 6.66%), II(17.14%), III(11.42%),IV( 1.9%) .