Three-component synthesis of 4-amino-2-aryl-2H-pyrimido- [1,2-b][1,3]benzothiazole-3-carbonitriles using metal-organic framework MIL-53(Fe) as catalyst

A simple and convenient approach was suggested for the synthesis of 4-amino-2-aryl-2H-pyrimido- [1,2b][1,3] benzothiazole-3-carbonitriles through a one-pot three-component reaction of 2- aminobenzothiazole, aldehydes, and malononitrile in the presence of metal organic frameworks. The products were obtained in excellent yields and short reactions times using MIL-53(Fe) as catalyst. The prepared nanocatalyst maintained its unique framework after the reaction and could be recycled and reused several times without significant loss of activity. The catalyst was characterized by FT-IR, SEM and EDX analysis