Synthesis of benzopyranopyrimidine using nanotriethanolammonium trichloroacetate

Multi-component reaction(MCR) protocol with environmentally benign solvents and catalytic system is one of the most suitable strategies, wich meets requirements green aspects of chemistry for developing libraries of medicinal scaffold[1]. Benzopyranopyrimidines show interesting features which make them attractive targets for the synthesis via MCR[2]. Benzopyranopyrimidine display a wide range of biological activities including antifungicidal, anti-bactericidal[3].Herein, we report an efficient and simple method for the synthesis of newbenzopyranopyrimidineviaapseudo four-component reaction of salicylic aldehydes, malononitrileand various amines in the presence of a catalytic amount of nanotriethanolammoniumtrichloroacetate[TEATCA] in EtOH at 95 C (Figure I ).In conclusion, using nontoxic, environmental friendly catalyst and having easy work make this method attractive.