A Novel Procedure For The Rapid And Stereoselective Synthesis Of Fused Pyrimidines

The chemistry of heterocyclic compounds is the most important in the discovery of new drugs. Among all heterocyclic compounds, pyrimidines areone of the most important heterocycles.various fused pyrimidines like purines, quinazolines, pyridopyrimidines, triazolopyrimidines, pyrazolopyrimidines, pyrimidoazepines, furopyrimidines and pyrrolopyrimidines were studied in the past decade and were found to possess remarkable biological andpharmacological activities including anticonvulsant, antibacterial, antifungal, antiviral andanticancer properties.[1,2] In this paper we report a new, rapid procedure involving the addition reaction of ninhydrine and 4-amino-1,3-dimethyluracil, which leads to dihydroxyindenopyrrolopyrimidinesunder Reflux conditions in ethanol (Figure 1). This reaction proceeded without any catalyst in excellent yields and the other advantages of this work are simple work-up, no toxic byproducts and milder reaction conditions. All structures were confirmed by IR, MS, 1H- and 13C-NMR Spectra.