Synthesis of 2-amino-4-azido-5-phenylfuran-3-carbonitrile derivatives via multi-component reactions from Arylglyoxals and Malononitrile and Sodium azide.

Due to the high importance of furans in biologically active molecules, a number of synthetic approaches have been devised and published as alternatives to the classical methods represented by the Knorr, Paal-Knorr, and Hantzschprotocols [1-3]. In this communication, we report synthesis of furan derivatives from arylglyoxals and malononitrile, in the presence of sodium azide in water as solvent at room temperature. The product was identified by IR, 1H-NMR and 13C-NMR Spectra.