An Afficient Approach To Catalyst-Free, One pot Synthesis Of New Fused Heterocyclic Compounds

Heterocyclic compounds especially, nitrogen containing heterocycles are important natural and synthetic materials. Among them, the benzo[g]quinoline-5,10-dione derivatives exhibits excellent biological activities in pharmaceuticals. Some structures of naturally occurring benzo[g]quinoline-5,10-dione skeletonsare Cleistopholine(antimicrobial and anticancer), Phomazarin(cytotoxic), Jadomycins(antibacterial, anti-tumor, antiviral, cytotoxic, and Aurora-B kinase inhibitory activities)[1,2]. This work represents a successful synthesis of a new class of benzo[g]Imidazo[1,2-a]quinolinedione derivatives via four components reaction between 1,1- bis(methylthio)-2-nitroethylene, ethylene diamine, 2-hydroxy-1,4- naphthoquinone and aromatic aldehydes (Figure 1). This reaction proceeded without any catalyst. The ready availability of the startingmaterials, good yields of the products and the reaction‘s simplicity of the process are theother advantages of this method. All structures were confirmed by IR, MS, 1H- and 13C-NMR Spectra.