An efficient synthesis of 2-amino-tetrahydro-4H-pyrans using a basic catalyst

4H-Pyrans and 4H-pyran-annulated hetrocyclic scaffolds represent a privileged structural motif well distributed in naturally occurring compounds with a broad spectrum of significant biological activities that include anticancer, cytotoxic, anti-HIV, antihyperglycemic and etc [1-3]. The conventional synthetic method for the preparation of this type of compounds is based on the condensation of ethyl acetoacetate with aromatic aldehydes and malononitrile. For this purpose, a variety of catalysts have been used to facilitate the reaction that has some disadvantages such as toxicity, expensiveness and difficulty in the preparation of the catalyst. In this work we report the applicability of a basic organo-catalyst for the simple, efficientsynthesis of 4H-pyran derivatives. The present methodology suggests several advantages such as ease of the preparation, reusability of the catalyst, high yields, simple and green procedures, low cost, short reaction times, easy work-up and preformation of the reaction in water as a green solvent(figure 1).