Synthesis of novel organosilylvinyl substituent bis-1,2,3-triazole derivatives having antibacterial activity

The copper(I)-catalyzed 1,3-dipolar Huisgen cycloaddition (CuAAC) reaction of azides and terminal alkynes for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazole derivatives is an important example of click chemistry. These compounds are useful as pharmaceutical agents, agrochemicals, dyes, corrosion inhibitors, photo stabilizers and photographic materials [1]. It is significant that modification of 1,2,3-triazole derivatives with organosilicon groups possibility provides biologically active compounds, which we investigated in this work. Organosilicon compounds attract scientific attention for some reasons, especially due to a number of interesting results in the field of their biological action, as derivatizing and protecting reagents, intermediates in organic synthesis, and reducing agents. Recently, successful synthesis of a variety of organosilicon derivatives was reported in our laboratory [2]. The in vitro antibacterial activities of mono and di-1,4-disubstitude 1,2,3-triazoles and organosilylvinyl derivatives were tested on several Gram-positive and/or Gramnegative bacteria. The results exhibit the promising antibacterial activity for organosilylvinyl substituent bis-1,2,3-triazole derivatives.