The One-Pot Synthesis of Pyrimidine Derivatives by Using Nano Silica Boron Sulfuric Acid as an Efficient Catalyst under Solvent-Free Conditions

In recent decades, One-Pot multicomponent reactions are known as important and environmentally benign processes in synthetic chemistry because they decrease the number of steps and reduce energy consumption and waste production [1].Pyrimidine and its derivatives constitute an important class of natural and synthetic products that possess significant biological and pharmaceutical properties [2]In particular, functionalized pyrimidinessuch as fused pyrimidinones with an arylidene part are essential heterocyclic motifs in antitumor agents. Regarding the importance of arylideneheterobicyclicpyrimidinonesand the great need for environmentally benign chemical productions, the development of suitable green synthetic methods for these compounds has attracted considerable interest. Recently, more attention has been paid to the application of solid acids in organic synthesis because of many advantages such as their easy handling and separation, reducing reactor corrosion problems and environmentally safe disposal [3]. So, herein we report a new, convenient, mild, andefficient procedure for One-Pot , three-component synthesis of pyrimidine derivativesin the presencenanosilica boron sulfuric acid (NSBSA) as an effective solid acid catalyst under solvent-freeconditions.