Di-Sulfonic Acid Imidazolium Chloroaluminate [Dsim]AlCl4 as an efficient catalyst for the preparation of hexahydroquinoline derivatives

Quinoline derivatives with a 1,4-dihydropyridine scaffold are promising structures because of their pharmacological properties.Hexahydroquinolines (HHQs) have used as anti-bacterial, anti-hypertensive, antimalarial, anti-inflammatory, antiasthamatic, and tyrosine kinase inhibiting agents [1,2]. Some methods and catalysts have been reported for the preparation of HHQs [3,4]. In this work, we have used di-Sulfonic acid imidazolium chloroaluminate[Dsim]AlCl4as an efficient, heterogeneous, and reusable catalyst for the synthesis of hexahydroquinolines by the One-Pot multi-component condensation reaction of dimedone aryl aldehydes, (5,5-dimethylcyclohexane-1,3-dione), β-ketoesters and ammonium acetate under solvent-free conditions (Figure).