Efficient synthesis of 3,6,6,9- tetra methyl-4,8- diazaundecane-2,10-dione dioxime as a radiotracer ligand

Duringrecent years, numerous brain imaging radiopharmaceuticals have been synthesized including N-isopropyl-p-I--iodoamphetamine(IMP),N,N,N-trimethyl-N-2-hydroxy-3-methyl- 5-I-iodobenzyl-1,3-propane-diamine(HIPDM)Tl-dimethyldithiocarbamate(DDC)Tc--d,lhexamethylpropylene- amine (HMPAO) and Tc-l,l-ethylcystinatedimer (ECD) Ligands are very important as an excellent brain imaging agent[1]. In this report, an efficient One-Pot procedure for the synthesis of diazadioxime was described.Treatment of ketoxime with alkylamine followed by NaBH4 in dry ethanol afforded the corresponding diazadioxime in good yield[2]. The procedure is easy to perform and does not require tedious purification procedures.All reagents are commercially available and inexpensive.This method is useful for commercial mass production[3,4].