Efficient synthesis of pyrano[2,3-d]pyrimidine-2,4(1H,3H)-diones in the presence of organo catalyst

Barbituric acid and its derivatives show a variety of pharmaceutical properties. Pyrano[2,3-d]pyrimidine-2,4(1H,3H)-diones as important derivatives of barbituric acid has also received significant attention from many pharmaceutical and organic chemists essentially because of the broad spectrum of their biological and pharmaceutical properties such as antitumor, analgesic, antibacterial, and fungicidal activities [1-3]. In this work, we have introduced an efficient, simple and green method for the synthesis of pyrano[2,3-d]pyrimidine-2,4(1H,3H)-diones derivatives using a saccharin as an efficient organo catalyst. Easy work-up procedure, mild and green reaction conditions, high reaction times and excellent yields of the products are significant advantages of this method(figure 1).