Eggshell-supported-Cu(I) metphormine complex: An efficient and green catalyst for synthesis of 1,2,3-triazoles in water

1,2,3-Triazoles are important nitrogen heterocyles which display many interesting properties including antibacterial, antiallergic, anti-HIV, GSK-3 inhibiting, and antineoplastic activities[1-3]. Copper-catalyzed azide-alkyne cycloaddition (CuAAC), also known as the ―click reaction,‖ has become one of the most important reactions for the preparation of 1,2,3-triazoles. This important reaction is widely applied in organic synthesis, biochemistry, medicinal chemistry, and material science[4]. In this letter we wish to report an efficient, safe, and green One-Pot synthesis of 1,4-disubstituted 1,2,3-triazoles from benzyl chloride/alkyl halides, sodium azide, and alkynes catalyzed by eggshell-supported-Cu(I)Metphormine complex in water at room temperature.