Introduction of a new organo-catalyst for the synthesis of 2-aminotetrahydro- 4H-pyrans derivatives

Pyran derivatives are ordinary structural subunits in a variety of important natural products, including carbohydrates, alkaloids, polyether antibiotics, pheromones and iridoids. Tetrahydrobenzo pyrans are important class of heterocyclic scaffolds in the field of drugs and pharmaceuticals. These compounds are widely used as anti-coagulant, diuretic, spasmolytic, anticancer and anti-anaphylactic agents. Numerous methods have been reported for the synthesis of 4Hbenzo pyrans. Each of these methods has its own advantages with some limitations such as extreme experimental conditions, long reaction times, low yields and effluent pollution [1,4]. Herein, we wish to report the efficient method for the synthesis of 2-amino-tetrahydro-4Hpyrans using hydantoin as an efficient organo-catalyst. The most important advantages of this method are: simplicity, mild reaction conditions, easy work-up, short reaction times, high yields of the products and reusability of the catalyst (figure1).