Nano-CuO catalyzed the formation of 4,5-Bis(phenylimino)-2-alkyliminoimidazolidinesNano-CuO catalyzed the formation of 4,5-Bis(phenylimino)-2-alkyliminoimidazolidines

Nitrogen containing heterocyclic systems are of interest because they are key intermediates of natural products [1]. Tetrahydroimidazoles (imidazolidines) display a significant role as intermediates in the nucleotide biosynthesis [2]. Herein, we report that nano-CuO is an efficient catalytic system for guanylation of amines with carbodiimides under mild reaction conditions. A One-Pot method for direct synthesis of 4,5-Bis(phenylimino)-2- alkyliminoimidazolidines 5via the reaction ofaniline derivatives1,carbodiimides2,andN,N - diphenyloxalimidoyl dichloride in the presence of CuO-NPs was developed.The structures of products5were assigned by IR, 1H NMR, 13C NMR, and mass spectral data. Various features of these transformations will be presented and discussed.