One-pot, multi-component synthesis of various 5-amino-4-carbonitrile pyrazole derivatives with green conditions

Pyrazole and derivatives are key substructures in a large variety of compounds with important biological activities and pharmacological properties [1]. Multi-component reactions (MCRs) have emerged as an attractive and powerful strategy for organic synthesis compared to multistep reactions due to the creation of several new bonds in a One-Pot reaction, low number of reaction and purification steps, selectivity, synthetic convergence, high atomeconomy, simplicity, and synthetic efficiency [2].In fact, development of MCRs can lead to new efficient syntheticmethodologies to afford many small organic compounds in the field of modern organic, bioorganic, and medicinal chemistry [3]. We have developed a highly efficient and green One-Pot methodology for the synthesis of a wide range of 5-amino pyrazole-4-carbonitrile derivatives, which are often encountered in biologically and pharmacologically actives compounds. The present methodology requires low catalyst loading as a mild Lewis acid catalyst. The most important advantages of this method include the use of cost-effective and mild transition metal catalyst, aqueous conditions, excellent yields, clean and simple work-up procedure, and avoidance of using hazardous organic solvents that makes this method an instrumental alternative to the previous methodologies for the scale-up of these One-Pot three-component reactions.