An Eficient Strategy for the One-pot Multicomponent Synthesis of Spiroacenaphthelyne-Pyrazoloquinoline Derivatives

Over the past few years, multi-component reactions (MCRs) have been designed to be an efficient and potent tools and have become a significant area of research in organic chemistry. MCRs are used for the synthesis of biologically active compounds in medicinal chemistry and complex product from simple and readily available starting materials without isolation of intermediates in short time with high purity, maximum selectivity and in a minimum number of synthetic steps and good yields [1,2]. Pyrazolone derivatives have omnipresence applications in the development of acaricides, dyes, fungicides, herbicides, insecticides, inhibitors and reagents [3]. Herein, we report an efficient synthesis of spiroacenaphthelyne spiro[pyrazoloquinoline acenaphthylene] 4 based on a One-Pot three-component reaction of acenaphthoquinone 1, pyrazolone 2, arylamines 3 (Scheme 1). In this work, the structures of all compounds were deduced from their analysis, IR, 1H NMR,13CNMR spectra. The mass spectrum of 4 displayed the molecular ion peak at appropriate m/z value, which is in agreement with the proposed structure.