Nano triethanolammonium trichloroacetate as new catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives

Nitrogen-containing heterocyclic compounds are widespread in nature, and their applications to biologically active pharmaceuticals, agrochemicals, and functional materials are becoming more and more important[1]. The development of new efficient methods to synthesize N-heterocyclic with structural diversity is one major interest of modern synthetic organic chemists [2-3]. Herein, we wish to report a novel three-component synthesis of 1Hpyrazolo[ 1,2-b]phthalazine-5,10-dione derivatives using nano triethanolammonium trichloroacetate [TEATCA] as catalyst for condensation reaction of phthalhydrazid, malononitrile, and aldehydes in EtOH at 110 °C( FigureI). This method offers several advantages such as inexpensive catalyst, easy synthetic procedure, use of greener solvent (EtOH), high yield.