Enhanced electrochemical signal of BUP drug on a magnetic nano-mound structured surface

Herein, we report a highly sensitive voltammetric determination of buprenorphine using a citrate stabilized magnetic nanocrystal (CS-MNCs) modified carbon paste electrode (CP). The buprenorphine electro-oxidation peak current ip at CS-MNs/CP electrode was 10 fold higher than that of unmodified CP electrode. CS-MNCs/CP electrode detects buprenorphine in the linear range of 0.02-68.0 μM with a detection limit (DL) of 4.3 nM. Fast response time, high sensitivity and ease of preparation method without using any specific electron transfer mediator or specific reagent are the advantages of the sensor. The modified electrode was applied to the determination of buprenorphine in human biological fluid at micromolar level without any pretreatment or separation step.