Electrochemical determination of acetaminophen by carbon paste electrode modified with Nickel-Cobalt salen complexes encapsulated in nano zeolite NaX

Acetaminophen (AC) is a combination of drugs, which are commonly used to treat pain and fever. The liquid chromatography [1] and spectrophotometry [2] analytical techniques have been developed for AC quantification. But, these methods are often expensive and usually need to pretreatment or toxicity solvents [3]. AC is an electro-active compound; therefore electrochemical technique for the determination of AC drew a lot of attention in the last few years due to its simplicity, low cost, high sensitivity and selectivity [3,4]. In this study, a type of carbon paste electrode using Ni-Co salen complexes encapsulated in nanozeolite NaX was prepared and was used for electro-catalytic oxidation of AC in biological samples.