5-Fluorouracil electrochemical modified sensor

5-Fluorouracil is an antimetabolite fluoropyrimidine analog and prescribed as a drug in chemotherapy. 5-Fluorouracil is a widely used chemotherapy drug for a wide range of cancers such as breast, stomach, pancreatic, skin, gullet and bowel cancer [1]. The carbon paste electrode modified with graphene quantum dot and 1-butylpyridinium bromide was fabricated and used as electrochemical sensor for determination of 5-fluorouracil with detection limit 0.5 nM. The fabricated sensor improved the oxidation current of 5-fluorouracil and reduced the oxidation over-potential of this anticancer drugs. The novel sensor was used for determination of 5-fluorouracil in injection and serum samples.