Magnetically Nanoparticles of Copper Ferrite@antimony: An Efficient Catalyst for Synthesis of Biscoumarins from 4-Hydroxycoumarin and Aromatic Aldehydes

Coumarins are biologicaly active compounds with antifungal, antineoplastic, antibacterial, spasmolytic or cytotoxic activity. 4-Hydroxycoumarin and its derivatives such as dicoumarol are known as anticoagulants [1-2]. Bis (4-hydroxycoumarin-3-yl) methanes are obtained by the condensation of two molecules of 4-hydroxycoumarin with one reusable catalyst [3]. These subjects prompted us to prepare CuFe2O4/Sb as an efficient nanocatalyst toward synthesis of biscoumarins with 4-hydroxycoumarin and aromatic aldehydes in ethylene glycol (Scheme 1). High activity and easy separation makes, CuFe2O4/Sb as an ideal catalyst for this transformation. The procedure has the advantages of mild reaction conditions, high yields of products, short reaction time, and simple experimental technique, making it a useful and attractive process.