Pd(II)-Supported Complex on Fe3O4@SiO2@SBA-15 for Heck Reaction

Magnetite nanoparticles were prepared via co-precipitation method and then successively covered by silica and mesoporous silica (SBA-15) layers [1]. N-(3-(Trimethoxysilyl) propyl) picolinamide, obtained from the reaction between 3-aminopropyltrimethoxysilane (APTMS) and picolinoyl chloride [2], was reacted with Fe3O4@SBA-15 as supported ligand (Fe3O4@SBA-15-PPA) for Pd(II), Scheme 1. Finally, functionalized magnetic mesoporous nanoparticles were reacted with PdCl2 to afford supported Pd(II)-complex that showed excellent efficiency in Heck Reaction of alkenes with aryl halides [3], Scheme 2. The catalyst could be easily separated from the reaction mixture by an external magnet and could be recovered and reused several times.