An Green and Efficient One-Pot Synthesis of Some Chalcone Derivatives by Zeolite-MnFe2o4 Nanocomposites at Room Temperature

Chalcones (1,3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the flavonoid family, which possess a number of interesting biological properties such as antioxidant, anticancer, antimicrobial, antiprotozoal, antiulcer, antihistaminic and anti-inflammatory activities. In the present study, a series of chalcone derivatives were synthesized and their structure also confirmed. The compounds were synthesized by various aldehydes and acetophenone derivatives in the ratio of 1: 1 mmol in the presence of a Zeolite/MnFe2O4 based nanocomposites under various solvents and solvent-free conditions. At all experiments, the desired products were synthesized successfully. The described novel synthesis method proposes several advantages of safety, mild condition, short reaction times, high yields, simplicity and easy workup compared to the traditional method of synthesis. The structures of the synthesized compounds were confirmed by IR, SEM, EDAX and NMR analysis. This method is an easy, rapid, and high yielding reaction for the synthesis of chalcones derivatives.