Correlation of Celecoxib Solubility in Aqueous Solutions Containing Some Choline Based Deep Eutectic Solvents as Sustainable Solvents

Deep eutectic solvents (DESs) have a wide variety of potential and existing applications. Based on the fact that the choline chloride (ChCl) is a complex B vitamin and widely used as food additive, the choline-based DESs are generically regarded as environmentally “harmless” and thus, accepted as “non-toxic”. This work provides the solubility measurement of celecoxib (CLX) in binary solvent mixture of water and two DESs at various temperatures (298.15 K, 303.15 K, 308.15 K and 313.15 K). The observed solubility data was subjected to evaluate the relative performance of a number of models including Apelblat, Yalkowsky and Jouyban–Acree, e-NRTL and Wilson models for their correlation efficacy. It was found that the used models can satisfactorily correlate the solubilities of CLX in the mixture solvents under different temperatures.