Electrochemical kinetics and mechanism study of Raloxifene drug

Electrochemical methods are widely applied to the study of the electroactive compounds. Voltammetric techniques are frequently and routinely used today to obtain information about homogeneous reactions coupled with electron transfer [1]. In this work the electrochemical oxidation of raloxifene was studied in the absence and presence of 2-mercaptopyrimidin in aqueous-ethanol solution on the surface of a glassy carbon electrode by cyclic voltammetry. The results indicate electrode reaction process is a quasi-reversible kinetics and the exchange of two electrons and two protons are involved in the process [2]. Investigation of voltammogram at different concentrations of raloxifene shows that raloxifene is oxidized at the surface of the electrode and its oxidized form partially participated in a side reaction such as dimerization. Investigation of raloxifene cyclic voltammograms in the presence of 2-mercaptopyrimidine shows that at high concentration of 2-mercaptopyrimidine and at low scan rates, a catalytic reaction is performed. As a result of the relative stability of oxidized form of raloxifene, it doesn t contribute in an addition reaction with nucleophiles such as diethyl amine. However raloxifene perform an addition reaction with 2-mercaptopyrimidine at high concentrations of it. During the electrode oxidation raloxifene lose two electrons and the raloxifene-oxide has positive charge [3]. Due to the structure of the raloxifene-oxide, the positive charge is distributed throughout the molecule and has a resonant structure. This resonance structure causes the oxidative stability of raloxifene and its reluctance to react with these compounds.