Determination of Penicillamine using CPE modified with 4,4 -Biphenol and MWCNTS

Penicillamine (PA) is a strong chelating agent and can react with the majority of heavy metal ions.The outstanding metal binding capability is reflected in the pharmaceutical importance of PA [1]. Multi-walled carbon nanotubes (MWCNTs), which is a nanomaterial, is now in mass production because of its excellent mechanical and electrical properties [2]. In this work, a carbon paste electrode modified with MWCNTS and 4,4 biphenol was prepared and applied for the determination of d-penicillamine. It was found that under an optimum condition (pH 7.0), the oxidation of d-penicillamine at the surface of such an electrode occurs at a potential about 340 mV. The diffusion coefficient (D = 1.23 × 10−5 cm2/s) and the electron transfer coefficient (α = 0.52) for d-penicillamine oxidation were also determined.linear dynamic range of 1µM-700 µM and detection limit of penicillinaminewas obtained 0.219 µM.