شماره ركورد كنفرانس
4522
عنوان مقاله
Peptide target therapy of NF-κB, chemical inhibitor of Bcl-2 and mdr1 gene expression in Acute Myeloid Leukemia (AML) cell line
پديدآورندگان
masoud Gandomkar Dept. of Medical Biotechnology, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran , Mohammad Rahmati Dept. of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , Nosratallah Zarghami Dept. of Medical Biotechnology, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran , Hassan Darushnejad Dept. of Medical Biotechnology, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
تعداد صفحه
۱
كليدواژه
AML , HL 60 , ABT , 737 , NBD peptide , mdr1
سال انتشار
۱۳۹۲
عنوان كنفرانس
هشتمين همايش بيوتكنولوژي جمهوري اسلامي ايران و چهارمين همايش ملي امنيت زيستي
زبان مدرك
انگليسي
چكيده فارسي
Acute myeloid leukemia (AML) is a hematological malignancy that the cause of death in adults. In this cancer over expression of Bcl-2 and P-glycoprotein are the two cause of resistance. NF-κB, a transcription factor that enhance expression of the panel of gene, include the two mentioned above molecules. NF-κB is a good target for treatment of cancer and overcoming to drug resistance in cancer therapy. ABT-737 is a novel anti Bcl-2 small molecule drug that is has strong potency to chemotherapy as a new drug.
كشور
ايران
لينک به اين مدرک