Traceable Smart Hydrogel with High Capacity for Efficient Drug Administration

Accurate, controllable, and sufficient drug delivery is one of the most remarkable potentials of hydrogels, which has not yet been fully implemented. Because embedding all these options in a single system requires complex and sagacious design. Nanocomposite hydrogels based on smart polymers and multi-branched structures are a new class of biomaterials for this purpose. In the present work, a hydrogel based on hyperbranched polyglycerol (HPG), stimulus-responsive poly[2-(dimethylamino)ethyl methacrylate (PDMAEMA), and traceable Fe3O4 nanoparticles has been designed and prepared. The results indicate the successful preparation of this hydrogel and its high potential for drug delivery applications.