The Release Behavior of Tetracycline hydrochloride (TCH) from Carboxymethyl Chitosan (CMCS)/ Montmorrilonite (MMT) Microcapsules

Abstract Microcapsules (MCs) were prepared by the emulsion crosslinking method, where carboxymethyl Chitosan (CMCS)/montmorrilonite (MMT) served as the shell materials, and tetracycline hydrochloride (TCH) antibiotic as core drug. MCs were characterized by XRD, TGA/DTGA, and SEM. The in vitro drug release behavior of TCH from MCs was investigated in different buffer media (pH=4,7 and 9). The release in alkaline medium was higher as compared to acidic and neutral media and MCs displayed a pH-dependent drug release behavior. The drug release kinetic was investigated and a swelling-release model was proposed.